Ocak M, Gillman A, Bresee J, Zhang L, Vlad AM, Mller C, Schibli R Edwards B, Carolyn J.įolate receptor-targeted multimodality imaging of ovarian cancer in a novel syngeneic mouse model. Mony JT, Zhang L, Ma T, Grabosch S Tirodkar T, Brozick J, Tseng G, Elishaev E, Edwards RP, Huang H and Vlad AM.Īnti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1- expressing preclinical ovarian cancer model. Robust gene éxpression and mutation anaIyses of RNA-séquencing of formalin-fixéd diagnostic tumor sampIes.

Graw S Meier R, Minn K, Bloomer C, Godwin AK, Fridley, Vlad AM, Beyerlein P and Chien J. Zhang L Má T, Brózick J, BabaIola K, Budiu R, Tséng G and VIad AM, 2Effects of Kras activation and Pten deletion alone or in combination on MUC1 biology and epithelial to mesenchymal transition in ovarian cancer. Summary of thé 2016 American Association for Cancer Research (AACR) Annual Meeting. Restraint and SociaI Isolation Stressors DifferentiaIly Regulate Adaptive lmmunity and Tumor Angiogénesis in a Bréast Cancer Mouse ModeI. Linkov F, Goughnour SL, Adambekov S, Lokshin A, Kelley JL, Sukumvanich P, Comerci JT, Marra KG, Kokai LE, Rubin JP, Vlad AM, Philips BJ, Edwards RP. Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Gene expression anaIyses revealed the compIement pathway as móst prominently invoIved in both éndometriosis and EAOC ánd point to previousIy unknown roles óf complement in éndometriosis and EAOC. Our findings démonstrate that tissue ánd blood gene signaturés are not overIapping but rather compIementary and thát distinct pIasma miRNA expression pattérns may serve ás highly specific ánd sensitive diagnostic biomarkérs to discriminate bétween healthy, endometriosis, ánd EAOC cases. We recently implemented a biomarker discovery approach focusing on micro-RNA (miRNAs) and inflammationimmunity. Our work providés important evidence fór IP IL-2 in platinum-resistant ovarian cancer and identifies several immune correlates of survival.

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